On the Relationship Between Non-alcoholic Fatty Liver Disease with Body Composition and Bone Mineral Density in Overweight/Obese Adolescents

Background: Nonalcoholic fatty liver disease (NAFLD) is a health problem growing in line with the rising prevalence of obesity children and adolescents, which may be correlated different metabolic abnormalities such as osteoporosis. Objectives: This study aimed to evaluate possible relationship between NAFLD body composition bone mineral density (BMD) obese overweight adolescents. Methods: cross-sectional encompassed 70 adolescents aged 11 - 18 years was conducted during March 2016 September Mashhad, Iran. Anthropometric parameters blood biomarkers were measured. Fat mass, fat-free BMD determined using dual-energy X‐ray absorptiometry (DXA) scans, also assessed Fibroscan. All statistical data analyzed SPSS software version 21. Multivariate linear regression fat content bone-related indicators, multivariate logistic detected NAFLD. Results: Total trunk mass significantly higher even after controlling for intervening factors (total OR = 1.27; 95% CI, 1.016 1.59, P 0.036; 1.35; 0.97 1.88, 0.045). Moreover, lower Z-score adjusting gender, BMI Z-score, ALT, index, total lean physical activity (β -0.285, 0.048). Conclusions: The findings present suggest that excess adipose tissue steatosis decreased overweight/obese